For the last 20 years, the "amyloid cascade hypothesis" has dominated research aimed at understanding, preventing, and curing Alzheimer's disease (AD). During that time researchers have acquired an enormous amount of data and have been successful, more than 300 times, in curing the disease in animal model systems by treatments aimed at clearing amyloid deposits. However, to date similar strategies have not been successful in human AD patients. Hence, before rushing into further clinical trials with compounds that aim at lowering amyloid-beta (Abeta) levels in increasingly younger people, it would be of highest priority to re-assess the initial assumption that accumulation of Abeta in the brain is the primary pathological event driving AD. Here we question this assumption by highlighting experimental evidence in support of the alternative hypothesis suggesting that APP and Abeta are part of a neuronal stress/injury system, which is up-regulated to counteract inflammation/oxidative stress-associated neurodegeneration that could be triggered by a brain injury, chronic infections, or a systemic disease. In AD, this protective program may be overridden by genetic and other risk factors, or its maintenance may become dysregulated during aging. Here, we provide a hypothetical example of a hypothesis-driven correlation between car accidents and airbag release in analogy to the evolution of the amyloid focus and as a way to offer a potential explanation for the failure of the AD field to translate the success of amyloid-related therapeutic strategies in experimental models to the clinic. Proceeds from the sale of this book go to support an elderly disabled person.
In contrast to the frequency of disorders of the autonomic nervous system, detailed knowledge on the diagnosis and treatment of ANS diseases is relatively scant among the majority of clinical specialists. Taking into account the prevalence of these disorders, good autonomic skills are mandatory to put patients on the right clinical track. This book serves as a guide for the everyday clinical management of ANS disorders from identifying key symptoms for autonomic involvement to comprehensive history taking. It helps determining the anatomic distribution of the disease as well as underlying autonomic syndromes and guides the reader towards transforming the clinical picture into a coherent explanation of the patient's autonomic problem. In addition, the book provides guidelines for choosing appropriate autonomic and laboratory tests and developing appropriate non-pharmacological and pharmacological management strategies. With cases from clinical experience and a list of available online resources, this book will be a useful guide for trainees and young doctors interested in autonomic disorders from the fields of neurology, internal medicine, cardiology, diabetes and urology.
'My Bedside Book Of Dreams' is one of the stationery series: 'Just A Few Words Journals - Pink Collection'.
This 6" x 9" notebook has a chic, matte-finish cover featuring the quote 'My Bedside Book Of Dreams' in typewriter font on a pink background.
The elegant journal consists of 100 ruled pages of cream paper and is a great addition to anyone's stationery collection.
- Makes a great personal journal for writing down your daily thoughts or for jotting down notes and ideas.
- 100 lined, opaque, cream pages.
- 6"x9" 15.2cm wide x 22.9 cm high.
- Smooth paper that is perfect for pens or pencils.
- Great for journaling or can be used as a blank diary.
- A wonderful back to school supply - exercise book.
- Can be used as a dream journal.