'My Bedside Book Of Dreams' is one of the stationery series: 'Just A Few Words Journals - Red Collection'.
This 6" x 9" notebook has a chic, matte-finish cover featuring the quote 'My Bedside Book Of Dreams' in typewriter font on a red background.
The elegant journal consists of 100 ruled pages of cream paper and is a great addition to anyone's stationery collection.
- Makes a great personal journal for writing down your daily thoughts or for jotting down notes and ideas.
- 100 lined, opaque, cream pages.
- 6"x9" 15.2cm wide x 22.9 cm high.
- Smooth paper that is perfect for pens or pencils.
- Great for journaling or can be used as a blank diary.
- A wonderful back to school supply - exercise book.
- Can be used as a dream journal.
Anyone who has passed the age of seventy needs to have a positive attitude to life in order to enjoy it. This book explains how 'older cavers' develop and maintain this attitude, as well as taking an active interest in their chosen sport. There is something here for everyone, not just the cavers and non-caving pensioners, but for the younger folk, who will, one day, hopefully, experience life as 'older folk'. The book is filled with amusing and interesting articles for fire-side, or bed-time reading. The philosophies embedded in the text may also stimulate the thoughts of the perceptive reader. John Gillett is an active caver who belongs to several UK caving clubs. He has a passionate belief in the societal benefits of education and has played an active part in developing and implementing ideas on this subject internationally. He is married, with one daughter and two grand-children. He lives in Gawsworth, Cheshire.
For the last 20 years, the "amyloid cascade hypothesis" has dominated research aimed at understanding, preventing, and curing Alzheimer's disease (AD). During that time researchers have acquired an enormous amount of data and have been successful, more than 300 times, in curing the disease in animal model systems by treatments aimed at clearing amyloid deposits. However, to date similar strategies have not been successful in human AD patients. Hence, before rushing into further clinical trials with compounds that aim at lowering amyloid-beta (Abeta) levels in increasingly younger people, it would be of highest priority to re-assess the initial assumption that accumulation of Abeta in the brain is the primary pathological event driving AD. Here we question this assumption by highlighting experimental evidence in support of the alternative hypothesis suggesting that APP and Abeta are part of a neuronal stress/injury system, which is up-regulated to counteract inflammation/oxidative stress-associated neurodegeneration that could be triggered by a brain injury, chronic infections, or a systemic disease. In AD, this protective program may be overridden by genetic and other risk factors, or its maintenance may become dysregulated during aging. Here, we provide a hypothetical example of a hypothesis-driven correlation between car accidents and airbag release in analogy to the evolution of the amyloid focus and as a way to offer a potential explanation for the failure of the AD field to translate the success of amyloid-related therapeutic strategies in experimental models to the clinic. Proceeds from the sale of this book go to support an elderly disabled person.